The reversed phase HPLC method has been developed for the simultaneous estimation of Etodolac & Thiocolchicoside in bulk and tablet dosage form. The proposed HPLC method utilizes Hypersil C18column (250mm × 4.6mm i.d., 5μm) and a mobile phase comprising of phosphate buffer (pH 6.8): acetonitrile in ratio of 70:30v/v with flow rate of 1ml/min. The retention time of THIO and ETO was found to be 3 min and 12min respectively. Quantitation was achieved with UV detection at 260nm.The method has been validated for Etodolac and Thiocolchicoside in terms of accuracy, precision, linearity, solution stability and robustness. The developed validated stability-indicating HPLC method was found to be simple, specific, accurate and reproducible for the determination of instability of these drugs in bulk and commercial products.
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